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pentobarbital will lower the extent or influence of pitolisant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Closely. Pitolisant publicity is lowered by fifty% if coadministered with potent CYP3A4 inducers.pentobarbital will lower the level or outcome of doxorubicin by influencing hepatic/intestinal enzyme CYP3A4 me